Multicatalytic Enantioselective Borrowing Hydrogen delta-Lactonization Strategy from beta-Keto Esters and Allylic Alcohols
By combining an iron-catalyzed borrowing hydrogen of allylic alcohols with an enantioselective organocatalyzed Michael addition of β-keto esters followed by a subsequent DBU-promoted lactonization different enantioenriched δ-lactones have been synthesized with good enantioselectivities. The valuable building blocks, featuring in some cases challenging quaternary stereocenters, have been obtained with >90% ee.
Références
- Titre
- Multicatalytic Enantioselective Borrowing Hydrogen delta-Lactonization Strategy from beta-Keto Esters and Allylic Alcohols
- Type de publication
- Article de revue
- Année de publication
- 2018
- Auteurs
- Quintard, Adrien, Roudier Mylène, and Rodriguez Jean
- Revue
- Synthesis
- Volume
- 50
- Ticket
- 4
- Pagination
- 785–792
- ISSN
- 0039-7881 DOI - 10.1055/s-0036-1588547
Soumis le 7 septembre 2022