Montmorillonite K-10 catalyzed cyclization of N-ethoxycarbonyl-N'-arylguanidines: Access to pyrimido[4,5-c]carbazole and pyrimido[5,4-b]indole derivatives.
Two new heterocycles, pyrimido[4,5-c]carbazole and pyrimido[5,4-b]indole, were prepd. in three steps from 3-aminocarbazole and 3-aminoindole, resp. The key Friedel-Crafts intramol. cyclization (e. g. of I) was realized under microwave irradn. using montmorillonite K-10 clay as a catalyst. The pyrimido[4,5-c]carbazole deriv. shows significant micromolar IC50 against cancer cell lines. Unlike similar carbazole and indolocarbazole compds., the mol. does not interfere with topoisomerase activity. [on SciFinder(R)]
Références
- Titre
- Montmorillonite K-10 catalyzed cyclization of N-ethoxycarbonyl-N'-arylguanidines: Access to pyrimido[4,5-c]carbazole and pyrimido[5,4-b]indole derivatives.
- Type de publication
- Article de revue
- Année de publication
- 2010
- Auteurs
- Debray, Julien, Zeghida Walid, Baldeyrou Brigitte, Mahieu Christine, Lansiaux Amelie, and Demeunynck Martine
- Revue
- Bioorg. Med. Chem. Lett.
- Volume
- 20
- Pagination
- 4244–4247
- ISSN
- 0960-894X
Soumis le 12 avril 2018