Département de chimie moléculaire

A review. Biol. programmed mol. recognition provides the basis of all natural systems and supplies evolution optimized functional materials from self-assembly of a limited no. of mol. building blocks. Biomols. such as peptides, nucleic acids and carbohydrates represent a diverse supply of structural building blocks for the chemist to design and fabricate new functional nanostructured architectures. In this context, we review here the chem. part of our Nanobio program, we have developed in Grenoble to manipulate such biomols., and org. mols., as well as assemble combinations thereof using a template assembled approach. With this methodol., we have prepd. new integrated functional systems exhibiting designed properties in the field of nanovectors, biosensors as well as controlled peptide self-assembly. Thus this mol. engineering approach allows for the rational design of systems with integrated tailor-made properties and paves the way to more elaborate applications by bottom-up design in the domain of nanobiosciences. [on SciFinder(R)]