Late-stage C–H amination of abietane diterpenoids
This study aims at highlighting the synthetic versatility of the rhodium-catalyzed C–H amination reactions using iodine(III) oxidants for the late-stage functionalization of natural products. Inter- and intramolecular nitrene insertions have been performed from various abietane diterpenoids, leading to the amination of the C-3, C-6, C-7, C-11 and C-15 positions. Ca. 20 aminated compounds have been isolated with yields of up to 86% and high levels of regio-, chemo- and stereoselectivities.
Références
- Titre
- Late-stage C–H amination of abietane diterpenoids
- Type de publication
- Article de revue
- Année de publication
- 2019
- Auteurs
- Lapuh, Maria Ivana, Dana Alejandro, Di Chenna Pablo H., Darses Benjamin, Durán Fernando J., and Dauban Philippe
- Revue
- Org. Biomol. Chem.
- Volume
- 17
- Ticket
- 19
- Start Page
- 4736
- Pagination
- 4736-4746
- Date de publication
- 03/2019
Soumis le 28 mars 2019