Intermolecular Rhodium(II)-Catalyzed Allylic C(sp3)–H Amination of Cyclic Enamides
The intermolecular rhodium(II)-catalyzed C(sp3)–H amination of enamides gives access to new 4-aminopiperidine derivatives that are useful building blocks in medicinal chemistry. This efficient transformation proceeds at room temperature with complete regio- and chemoselectivity in favor of the allylic C(sp3)–H bond, and has a broad functional group tolerance. In addition, the matched combination of the chiral complex Rh2(S-nta)4 [nta=(S)-N-1,8-naphthoylalanine] with an optically pure (S)-sulfonimidamide allows the isolation of allylic amines with excellent stereocontrol.
Références
- Titre
- Intermolecular Rhodium(II)-Catalyzed Allylic C(sp3)–H Amination of Cyclic Enamides
- Type de publication
- Article de revue
- Année de publication
- 2018
- Auteurs
- Rey-Rodriguez, Romain, Jestin Grégory, Gandon Vincent, Grelier Gwendal, Retailleau Pascal, Darses Benjamin, Dauban Philippe, and Gillaizeau Isabelle
- Revue
- Advanced Synthesis & Catalysis
- Volume
- 360
- Pagination
- 513–518
Soumis le 2 octobre 2018