Intermolecular Rhodium(II)-Catalyzed Allylic C(sp3)–H Amination of Cyclic Enamides

The intermolecular rhodium(II)-catalyzed C(sp3)–H amination of enamides gives access to new 4-aminopiperidine derivatives that are useful building blocks in medicinal chemistry. This efficient transformation proceeds at room temperature with complete regio- and chemoselectivity in favor of the allylic C(sp3)–H bond, and has a broad functional group tolerance. In addition, the matched combination of the chiral complex Rh2(S-nta)4 [nta=(S)-N-1,8-naphthoylalanine] with an optically pure (S)-sulfonimidamide allows the isolation of allylic amines with excellent stereocontrol.

Références

Titre
Intermolecular Rhodium(II)-Catalyzed Allylic C(sp3)–H Amination of Cyclic Enamides
Type de publication
Article de revue
Année de publication
2018
Revue
Advanced Synthesis & Catalysis
Volume
360
Pagination
513–518
Soumis le 2 octobre 2018