Département de chimie moléculaire

The intermolecular rhodium(II)-catalyzed C(sp³)–H amination of enamides gives access to new 4-aminopiperidine derivatives that are useful building blocks in medicinal chemistry. This efficient transformation proceeds at room temperature with complete regio- and chemoselectivity in favor of the allylic C(sp³)–H bond, and has a broad functional group tolerance. In addition, the matched combination of the chiral complex Rh₂(S-nta)₄ [nta=(S)-N-1,8-naphthoylalanine] with an optically pure (S)-sulfonimidamide allows the isolation of allylic amines with excellent stereocontrol.