Influence of Pre-organised Architecture on Cell Adhesion by Using Multivalent RGD Compounds.
Multimeric RGD-contg. compds. were designed to study the influence of ligand architecture on binding avidity. We report the synthesis of a series of tetrameric RGD compds. and their in vitro biol. evaluation. The further application of mol. dynamic simulations for structural studies of RGD derivs. reveals that the obsd. affinities correlate with the accessibility of segregated RGD motif. [on SciFinder(R)]
Références
- Titre
- Influence of Pre-organised Architecture on Cell Adhesion by Using Multivalent RGD Compounds.
- Type de publication
- Article de revue
- Année de publication
- 2016
- Auteurs
- Grassin, Adrien, Jourdan Muriel, Dumy Pascal, and Boturyn Didier
- Revue
- ChemBioChem
- Volume
- 17
- Pagination
- 515–520
- ISSN
- 1439-4227
Soumis le 12 avril 2018