Influence of Pre-organised Architecture on Cell Adhesion by Using Multivalent RGD Compounds.

Multimeric RGD-contg. compds. were designed to study the influence of ligand architecture on binding avidity. We report the synthesis of a series of tetrameric RGD compds. and their in vitro biol. evaluation. The further application of mol. dynamic simulations for structural studies of RGD derivs. reveals that the obsd. affinities correlate with the accessibility of segregated RGD motif. [on SciFinder(R)]

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Titre
Influence of Pre-organised Architecture on Cell Adhesion by Using Multivalent RGD Compounds.
Type de publication
Article de revue
Année de publication
2016
Revue
ChemBioChem
Volume
17
Pagination
515–520
ISSN
1439-4227
Soumis le 12 avril 2018