Département de chimie moléculaire

The redn. of the chiral, racemic nitrone 2-isopropyl-2,3-dimethyl-1-oxy-2,3-dihydroimidazol-4-one (MiPNO) provides a secondary hydroxylamine. Its O-acylation with O,O'-dibenzoyl-L-tartaric acid anhydride gives two diastereomers, that can be easily sepd. by selective dissoln. in orthogonal solvents. The recovery of the enantiopure nitrone is then carried out in a single step. The process allows the straightforward isolation of (R)- and (S)-MiPNO in 57{%} and 38{%} yield, resp., from rac-MiPNO. [on SciFinder(R)]