Indirect Tertiary Alcohol Enantiocontrol by Acylative Organocatalytic Kinetic Resolution

The stereocontrol of tertiary alcohols represents a recurrent challenge in organic synthesis. In the present paper, we describe a simple, efficient, and indirect method to enantioselectively prepare tertiary alcohols through a chiral isothiourea catalyzed selective acylation of adjacent secondary alcohols. This transformation enables the kinetic resolution (KR) of easily prepared racemic diastereoenriched secondary/tertiary diols providing both monoesters and starting diols in highly enantioenriched forms (s-value >200).

Références

Titre
Indirect Tertiary Alcohol Enantiocontrol by Acylative Organocatalytic Kinetic Resolution
Type de publication
Article de revue
Année de publication
2021
Revue
Organic Letters
Volume
23
Ticket
11
Pagination
4332–4336
ISSN
1523-7060
Soumis le 7 septembre 2022