Impedimetric biosensor for cancer cell detection.
Electrochem. impedance spectroscopy was evaluated for the label free detection of MCF-7 cancer cell in which c-erbB-2 receptor is overexpressed on the cell surfaces. Anti-c-erbB-2, used as a specific antibody, was immobilized on electrogenerated polypyrrole-NHS on electrodes via covalent linking. The polymer formation, the grafting of the antibody, and the recognition event with the cancer cells using MCF-7 as a model cell line, were characterized by using cyclic voltammetry and fluorescence microscopy. The impedimetric sensor showed high sensitivity from 100 to 10 000 cell/mL without needing any labeling step and represents an efficient transduction method for cell selective detection. [on SciFinder(R)]
Références
- Titre
- Impedimetric biosensor for cancer cell detection.
- Type de publication
- Article de revue
- Année de publication
- 2013
- Auteurs
- Seven, Basak, Bourourou Mariem, Elouarzaki Kamal, Constant Jean-François, Gondran Chantal, Holzinger Michael, Cosnier Serge, and Timur Suna.
- Revue
- Electrochem. commun.
- Volume
- 37
- Pagination
- 36–39
- ISSN
- 1388-2481
Soumis le 12 avril 2018