Département de chimie moléculaire

The ability of a rigid $\alpha$-Tn mimetic (compd. 1) to activate murine invariant natural killer T (iNKT) and human natural killer (NK) cells, two subsets of lymphocytes involved in cancer immunesurveillance, was investigated. For this purpose, the mimetic 1 was properly conjugated to a stearic acid contg. glycerol-based phospholipid (compd. 5) to be presented, in the context of the conserved non polymorphic major histocompatibility complex class I-like mols. (CD1d), to iNKT cells. On the contrary, the mimetic 1 was conjugated to a multivalent peptide-based scaffold (compd. 6) to induce NK cell activation. [on SciFinder(R)]