Highly Enantioselective One-Pot Copper-Catalyzed 1,4 Addition/Organocatalyzed alpha-Substitution of Enals

The asymmetric copper-catalyzed addition of dialkylzinc to enals followed by organocatalyzed one-pot aldehyde alpha-functionalization has been accomplished providing C–C, C–Cl or C–F bond formation. These simple procedures led to the creation of two contiguous stereocenters in excellent enantioselectivities (typical ee=99%). This methodology has been applied in the synthesis of (2S,3S) isomer of Valnoctamide®.

Références

Titre
Highly Enantioselective One-Pot Copper-Catalyzed 1,4 Addition/Organocatalyzed alpha-Substitution of Enals
Type de publication
Article de revue
Année de publication
2010
Revue
Advanced Synthesis & Catalysis
Volume
352
Ticket
11-12
Pagination
1856–1860
Soumis le 7 septembre 2022