Grafted dinuclear metal complexes, and use thereof as cellular microvesicle sensors.

The invention relates to novel grafted dinuclear metal complexes I, II (M = metal ion; i = 1-3; L = exchangeable ligand; X = -(CH2)m-NH-A, -CH2-NHC(O)-R-NH-A; R = 2-10 alkyl; A = H, fluorophore; m = 1-2; n = 1-3; Y = (CH2)p-NH2; p 0-12) and also the use thereof as sensors in a method for detecting and/or characterizing cellular microvesicles. III (prepn. given) was immobilized in microtiter plate wells activated with polyglutaraldehyde. Microvesicles released from TNF-$\alpha$-activated HMEC-1 cells were captured in the wells and detd. by immunoassay with antibodies to the microvesicles. [on SciFinder(R)]

Références

Titre
Grafted dinuclear metal complexes, and use thereof as cellular microvesicle sensors.
Type de publication
Brevet
Année de publication
2012
Patent Number
FR 2973029 A1
Soumis le 23 mai 2018