Glycosiderophores: Synthesis of tris-hydroxamate siderophores based on a galactose or glycero central scaffold, Fe(III) complexation studies.
A series of five new hexadentate tris-hydroxamate ligands based on a D-galactose or a glycerol scaffold have been synthesized. Protonation and ferric complex formation consts. have been detd. from soln. studies by potentiometric and spectrophotometric titrns. All ligands form 1:1 Fe:L complexes. The calcd. pFe values at pH 7.4 span over the range 19.2-23.0 depending on the scaffold and on the length of the spacers between hydroxamate and central scaffold and on the N-Me substitution. This new kind of artificial siderophores based on a glyco-scaffold is of interest as it opens up an easy way to modulate the pFe. [on SciFinder(R)]
Références
- Titre
- Glycosiderophores: Synthesis of tris-hydroxamate siderophores based on a galactose or glycero central scaffold, Fe(III) complexation studies.
- Type de publication
- Article de revue
- Année de publication
- 2012
- Auteurs
- Neff, Christelle, Bellot Francois, Waern Jenny-Birgitta, Lambert Francois, Brandel Jeremy, Serratrice Guy, Gaboriau Francois, and Policar Clotilde.
- Revue
- J. Inorg. Biochem.
- Volume
- 112
- Pagination
- 59–67
- ISSN
- 0162-0134
Soumis le 12 avril 2018