Functionalization of the A ring of pyridoacridine as a route toward greater structural diversity. Synthesis of an octacyclic analogue of eilatin.
In an effort to increase the structural diversity of pyrido[4,3,2-kl]acridines, compds. contg. amino substituents on the A ring were synthesized. The key-reactions involve regioselective electrophilic arom. substitutions. The methodol. was applied to the synthesis of the extended angular octacycle I, which conjugates the physicochem. and spectroscopic properties of the pyridoacridine skeleton with the ability of [1,10]phenanthroline ring for metal complexation. The 9-aminopyridoacridine II displays significant cytostatic activities against two cancer cell lines, and may be considered as a new lead in the search of active derivs. [on SciFinder(R)]
Références
- Titre
- Functionalization of the A ring of pyridoacridine as a route toward greater structural diversity. Synthesis of an octacyclic analogue of eilatin.
- Type de publication
- Article de revue
- Année de publication
- 2009
- Auteurs
- Bouffier, Laurent, Dinica Rodica, Debray Julien, Dumy Pascal, and Demeunynck Martine
- Revue
- Bioorg. Med. Chem. Lett.
- Volume
- 19
- Pagination
- 4836–4838
- ISSN
- 0960-894X
Soumis le 12 avril 2018