Formation of Quaternary Chiral Centers by N-Heterocyclic Carbene-Cu-Catalyzed Asymmetric Conjugate Addition Reactions with Grignard Reagents on Trisubstituted Cyclic Enones.
The copper-catalyzed conjugate addn. of Grignard reagents to 3-substituted cyclic enones allows the formation of all-carbon chiral quaternary centers. It is demonstrated in this article that N-heterocyclic carbenes act as efficient chiral ligands for this transformation. High enantioselectivities (up to 96 {%} ee) could be obtained for a variety of substrates. [on SciFinder(R)]
Références
- Titre
- Formation of Quaternary Chiral Centers by N-Heterocyclic Carbene-Cu-Catalyzed Asymmetric Conjugate Addition Reactions with Grignard Reagents on Trisubstituted Cyclic Enones.
- Type de publication
- Article de revue
- Année de publication
- 2010
- Auteurs
- Kehrli, Stefan, Martin David, Rix Diane, Mauduit Marc, and Alexakis Alexandre.
- Revue
- Chem. - A Eur. J.
- Volume
- 16
- Pagination
- 9890–9904, S9890/1–S9890/104
- ISSN
- 0947-6539
Soumis le 21 janvier 2019