Formation of all-carbon quaternary centers by copper-catalyzed asymmetric conjugate addition.
A review. This mini-review deals with a special, and challenging, aspect of the asym. conjugate addn.: the formation of all-carbon quaternary centers by reaction with Michael acceptors bearing a polysubstituted unsatn. Only copper catalysts allow this transformation, along with a careful choice of primary organometallics and chiral ligand. The resulting adducts are useful intermediates for the synthesis of more complex natural products. [on SciFinder(R)]
Références
- Titre
- Formation of all-carbon quaternary centers by copper-catalyzed asymmetric conjugate addition.
- Type de publication
- Article de revue
- Année de publication
- 2008
- Auteurs
- Alexakis, Alexandre, Vuagnoux-d'Augustin Magali, Martin David, Kehrli Stefan, Palais Laetitia, Henon Helene, and Hawner Christine.
- Revue
- Chimia (Aarau).
- Volume
- 62
- Pagination
- 461–464
- ISSN
- 0009-4293
Soumis le 21 janvier 2019