Formation of all-carbon quaternary centers by copper-catalyzed asymmetric conjugate addition.

A review. This mini-review deals with a special, and challenging, aspect of the asym. conjugate addn.: the formation of all-carbon quaternary centers by reaction with Michael acceptors bearing a polysubstituted unsatn. Only copper catalysts allow this transformation, along with a careful choice of primary organometallics and chiral ligand. The resulting adducts are useful intermediates for the synthesis of more complex natural products. [on SciFinder(R)]

Références

Titre
Formation of all-carbon quaternary centers by copper-catalyzed asymmetric conjugate addition.
Type de publication
Article de revue
Année de publication
2008
Revue
Chimia (Aarau).
Volume
62
Pagination
461–464
ISSN
0009-4293
Soumis le 21 janvier 2019