Fast Pd- and Pd/Cu-Catalyzed Direct C-H Arylation of Cyclic Nitrones. Application to the Synthesis of Enantiopure Quaternary α-Amino Esters.
Cocatalysis by pivalic acid or copper bromide allows a very fast, clean, and high-yielding palladium-catalyzed coupling of a large array of aryl, thienyl, and pyridyl halides with cyclic nitrones, including DMPO. The study of the reaction conditions, scope, and mechanism is presented. Applied to the chiral nitrone MiPNO (I), this transformation provides a straightforward access to enantiopure alpha-methyl-alpha-arylglycine esters.
Références
- Titre
- Fast Pd- and Pd/Cu-Catalyzed Direct C-H Arylation of Cyclic Nitrones. Application to the Synthesis of Enantiopure Quaternary α-Amino Esters.
- Type de publication
- Article de revue
- Année de publication
- 2012
- Auteurs
- Demory, Emilien, Farran Daniel, Baptiste Benoit, Chavant Pierre-Yves, and Blandin Véronique
- Revue
- J. Org. Chem.
- Volume
- 77
- Pagination
- 7901–7912
- ISSN
- 0022-3263
Soumis le 12 avril 2018