Expedient Construction of the [7–5–5] All-Carbon Tricyclic Core of the Daphniphyllum Alkaloids Daphnilongeranin B and Daphniyunnine D
A synthetic strategy for the construction of the [7–5–5] all-carbon tricyclic core of numerous calyciphylline A-type Daphniphyllum alkaloids has been developed using a key intramolecular Pauson–Khand reaction. A subsequent base-mediated double-bond migration and a regio- and stereoselective radical late stage allylic oxygenation provide access to the substitution patterns of daphnilongeranin B and daphniyunnine D.
Références
- Titre
- Expedient Construction of the [7–5–5] All-Carbon Tricyclic Core of the Daphniphyllum Alkaloids Daphnilongeranin B and Daphniyunnine D
- Type de publication
- Article de revue
- Année de publication
- 2012
- Auteurs
- Darses, Benjamin, Michaelides Iacovos N., Sladojevich Filippo, Ward John W., Rzepa Paula R., and Dixon Darren J.
- Revue
- Organic Letters
- Volume
- 14
- Pagination
- 1684–1687
Soumis le 25 septembre 2018