Expedient Approach to Chiral Cyclobutanones: Asymmetric Synthesis of Cyclobut-G
An efficient one-pot asymmetric synthesis of cyclobutanones from chiral enol ethers is described. The approach is illustrated with alkyl- and functionalized alkyl-substituted enol ethers (nine examples). A new enantioselective synthesis of cyclobut-G (Lobucavir) could thus be achieved.
Références
- Titre
- Expedient Approach to Chiral Cyclobutanones: Asymmetric Synthesis of Cyclobut-G
- Type de publication
- Article de revue
- Année de publication
- 2008
- Auteurs
- Darses, Benjamin, Greene Andrew E., Coote Susannah C., and Poisson Jean-François
- Revue
- Organic Letters
- Volume
- 10
- Pagination
- 821–824
Soumis le 2 octobre 2018