Enantioselective Synthesis of Medium-Sized-Ring Lactones by Organocatalytic Michael Addition Followed by Reductively Initiated Fragmentation
A new strategy for the rapid synthesis of enantioenriched medium-sized-ring lactones was developed. The method combines the organocatalytic Michael addition of cycloalkane-1,3-diones to alpha,beta-unsaturated aldehydes with a subsequent reductively initiated Claisen fragmentation, which allows access to 10- and 11-membered-ring lactones with 91 to >99 % ee.
Références
- Titre
- Enantioselective Synthesis of Medium-Sized-Ring Lactones by Organocatalytic Michael Addition Followed by Reductively Initiated Fragmentation
- Type de publication
- Article de revue
- Année de publication
- 2015
- Auteurs
- Roudier, Mylène, Constantieux Thierry, Quintard Adrien, and Rodriguez Jean
- Revue
- European Journal of Organic Chemistry
- Volume
- 2015
- Ticket
- 26
- Pagination
- 5709–5711
Soumis le 7 septembre 2022