Enantiocontrol over Acyclic Quaternary Stereocenters by Acylative Organocatalyzed Kinetic Resolution
In the present paper, we described the efficient enantioselective kinetic resolution (KR) of racemic diastereocontrolled secondary alcohols bearing a quaternary stereocenter using a commercially available chiral isothiourea organocatalyst. This methodology is a general KR leading to the enantiocontrol of acyclic quaternary stereocenter with high levels of stereoselectivity (s up to 185) on a large scope. The hydroxyl function can easily serve as a traceless group by oxidation or reduction process.
Références
- Titre
- Enantiocontrol over Acyclic Quaternary Stereocenters by Acylative Organocatalyzed Kinetic Resolution
- Type de publication
- Article de revue
- Année de publication
- 2022
- Auteurs
- Liu, Xueyang, Pons Jean-Marc, Monnier Valérie, Charles Laurence, Quintard Adrien, and Bressy Cyril
- Revue
- European Journal of Organic Chemistry
- Volume
- 2022
- Ticket
- 6
- Pagination
- e202101475
Soumis le 7 septembre 2022