Département de chimie moléculaire

Biosensors are describing comprising a conductive or semiconductive support and an intercalator polymer, wherein the intercalator polymer comprises monomer units of -P(Sp)(Im)- (I), wherein P is an electropolymerizable moiety selected among the group consisting of pyrrole, acetylene, phenol, aniline, thiophene, carbazole, and azulene; Sp is a spacer; and Im is an intercalator, such as a redox acridone deriv. of formula II. Methods for the detection of a DNA sequence with the biosensor are also provided, comprising the steps of: hybridizing the DNA sequence with a DNA probe for forming a double-stranded DNA (dsDNA), incubating the biosensor with the dsDNA for anchoring the dsDNA to the intercalator, and detecting the quantity of dsDNA on the biosensor. The intercalator polymer allows a better discrimination of dsDNA from single-stranded DNA. [on SciFinder(R)]