Département de chimie moléculaire

Four nickel(II)-salophen complexes contg. alkyl-imidazolium chains connected at the ortho or meta positions were prepd.: N,N'-bis(2-hydroxy-4-methyl-3H-imidazol-1-iumbenzylideneamino)phenylenediamine (1), N,N'-bis(2-hydroxy-3-methyl-3H-imidazol-1-iumbenzylideneamino)phenylenediamine (2), N,N'-bis(2-hydroxy-3-methyl-3H-imidazol-1-iumbenzylideneamino)methyl-3H-imidazol-1-iumphenylenediamine (3), and N,N'-bis(2-hydroxy-4-methyl-3H-imidazol-1-iumbenzylideneamino)methyl-3H-imidazol-1-iumphenylenediamine (4). They protect G-quadruplex DNA (G4-DNA) against thermal denaturation and show KA values in the range of 7.4 × 105 to 4 × 107 M-1 for G4-DNA models. Complex 4 exhibits an IC50 value of 70 nM for telomerase inhibition. [on SciFinder(R)]