Efficient conjugation of oligonucleotides through aromatic oxime formation.

The present work reports on the prepn. of oligonucleotide conjugates via the formation of arom. oxime linkage. The conjugation consists in the reaction between the oligonucleotide derivatized at 5'-extremity with a benzaldehyde moiety and an aminooxy reporter group. The conjugation was found highly efficient and was extended for the conjugation of phosphorothioate oligonucleotide. In addn., the stability of the so-formed oxime conjugate was investigated. [on SciFinder(R)]

Références

Titre
Efficient conjugation of oligonucleotides through aromatic oxime formation.
Type de publication
Article de revue
Année de publication
2009
Revue
Bioorg. Med. Chem. Lett.
Volume
19
Pagination
6534–6537
ISSN
0960-894X
Soumis le 12 avril 2018