A direct and versatile access to $\alpha$,$\alpha$-disubstituted 2-pyrrolidinylmethanols by SmI2-mediated reductive coupling.
Various $\alpha$,$\alpha$-disubstituted 2-pyrrolidinylmethanols are efficiently prepd. in a single step from ketones using a SmI2-mediated cross-coupling with 1-pyrroline N-oxide. The N-hydroxy-$\alpha$,$\alpha$-diphenylprolinol is also easily prepd. and resolved. [on SciFinder(R)]
Références
- Titre
- A direct and versatile access to $\alpha$,$\alpha$-disubstituted 2-pyrrolidinylmethanols by SmI2-mediated reductive coupling.
- Type de publication
- Article de revue
- Année de publication
- 2008
- Auteurs
- Burchak, Olga N., Philouze Christian, Chavant Pierre-Yves, and Py Sandrine
- Revue
- Org. Lett.
- Volume
- 10
- Pagination
- 3021–3023
- ISSN
- 1523-7060
Soumis le 12 avril 2018