A direct and versatile access to $\alpha$,$\alpha$-disubstituted 2-pyrrolidinylmethanols by SmI2-mediated reductive coupling.

Various $\alpha$,$\alpha$-disubstituted 2-pyrrolidinylmethanols are efficiently prepd. in a single step from ketones using a SmI2-mediated cross-coupling with 1-pyrroline N-oxide. The N-hydroxy-$\alpha$,$\alpha$-diphenylprolinol is also easily prepd. and resolved. [on SciFinder(R)]

Références

Titre
A direct and versatile access to $\alpha$,$\alpha$-disubstituted 2-pyrrolidinylmethanols by SmI2-mediated reductive coupling.
Type de publication
Article de revue
Année de publication
2008
Revue
Org. Lett.
Volume
10
Pagination
3021–3023
ISSN
1523-7060
Soumis le 12 avril 2018