A Diels-Alder-Based Total Synthesis of (-)-Kainic Acid.
An efficient synthesis of (-)-kainic acid, through a high-pressure-promoted Diels-Alder cycloaddn. of a vinylogous malonate derived from 4-hydroxyproline, is described. The bicyclic adduct could be converted into the natural product with complete stereocontrol.
Références
- Titre
- A Diels-Alder-Based Total Synthesis of (-)-Kainic Acid.
- Type de publication
- Article de revue
- Année de publication
- 2012
- Auteurs
- Orellana, Arturo, Pandey Sushil K., Carret Sébastien, Greene Andrew E., and Poisson Jean-François
- Revue
- J. Org. Chem.
- Volume
- 77
- Pagination
- 5286–5296
- ISSN
- 0022-3263
Soumis le 12 avril 2018