A Diels-Alder-Based Total Synthesis of (-)-Kainic Acid.

An efficient synthesis of (-)-kainic acid, through a high-pressure-promoted Diels-Alder cycloaddn. of a vinylogous malonate derived from 4-hydroxyproline, is described. The bicyclic adduct could be converted into the natural product with complete stereocontrol.

Références

Titre
A Diels-Alder-Based Total Synthesis of (-)-Kainic Acid.
Type de publication
Article de revue
Année de publication
2012
Revue
J. Org. Chem.
Volume
77
Pagination
5286–5296
ISSN
0022-3263
Soumis le 12 avril 2018