Département de chimie moléculaire

Targeting the tumor microenvironment is a promising strategy to detect and/or treat cancer. The design of selective compds. that co-target several receptors frequently overexpressed in solid tumors may allow a reliable and selective detection of tumors. Here we report the modular synthesis of compds. encompassing ligands of $\alpha$V$\beta$3 integrin and neuropilin-1 that are overexpressed in the tumor microenvironment. These compds. were then evaluated through cellular expts. and imaging of tumors in mice. We obsd. that the peptide that displays both ligands is more specifically accumulating in the tumors than in controls. Simultaneous interaction with $\alpha$V$\beta$3 integrin and NRP1 induces NRP1 stabilization at the cell membrane surface which is not obsd. with the co-injection of the controls. [on SciFinder(R)]