### Design of Iron chelators: Syntheses and iron (III) complexing abilities of tripodal tris-bidentate ligands.

A review. The interest in synthetic siderophore mimics includes therapeutic applications (iron chelation therapy), the design of more effective agents to deliver Fe to plants and the development of new chem. tools in order to study iron metab. and iron assimilation processes in living systems. The design of ligands needs a rational approach for the understanding of the metal ion complexing abilities. The octahedral arrangement of donor atoms is the most favorable geometry, allowing the max. possible distance between their formal or partial neg. charges. Hexadentate chelators, usually of the tris-bidentate type, can accommodate the metal coordination sphere and are well-suited to obtain high pFe values. The first part of this review is dedicated to selected synthetic routes, taking into account (i) the nature of the chelating subunits, connecting groups and spacers, (ii) the water-soly. and hydrophilic/lipophilic balance, (iii) the chirality and (iv) the possibility of grafting probes or vectors. In the second part, the authors discuss the role of the mol. design on complexing abilities (thermodn. and kinetics). The bidentate 8-hydroxyquinoline moiety offers an alternative to the usual coordinating hydroxamic acids, catechols and/or $\alpha$-hydroxycarboxylic acids groups encountered in natural siderophores. The promising results obtained with the tris-hydroxyquinoline-based ligand O-TRENSOX are summarized. O-TRENSOX exhibits a high and selective affinity for Fe(III) complexation. Its efficiency in delivering Fe to plants, iron mobilization, cell protection, and antiproliferative effects has been evidenced. Other chelators derived from O-TRENSOX (mixed catechol/8-hydroxyquinoline ligands, lipophilic ligands) are also described. Some results question the relevance of partition coeffs. to foresee the activity of iron chelators. The development of probes (fluorescent, radioactive, spin labeled) based on the O-TRENSOX backbone is in progress in order to get insights in the complicated iron metab. processes. [on SciFinder(R)]

### Références

Titre
Design of Iron chelators: Syntheses and iron (III) complexing abilities of tripodal tris-bidentate ligands.
Type de publication
Article de revue
Année de publication
2006
Revue
BioMetals
Volume
19
Pagination
349–366
ISSN
0966-0844
Soumis le 12 avril 2018