Design and synthesis of novel hybrid metal complex-DNA conjugates: Key building blocks for multimetallic linear DNA nanoarrays.
The authors describe here a short and efficient synthetic route for incorporating terpyridine based metal complexes at the 3'-extremity of both single and bis-oligonucleotide (bis-ODN) stretches to form novel metal complex-ODN conjugates. All single stranded mono and bis-ODN tethered metal complexes and the resp. duplex ODNs were characterized by CD spectroscopy and UV-visible melting expts. Duplexes formed by these hybrid metal complex-DNA conjugates showed around 4-5° stabilization with respect to the unmodified duplexes. Also hybridization of two complementary bis-ODN tethered metal complexes at different ratios in soln. gave rise to a self-assembled nanometric linear network, which was characterized by nondenaturing gel electrophoresis and TEM studies. Thus, the authors' simple synthetic strategy would contribute to develop multimetallic 2-dimensional-DNA nanoarrays where the authors can place different metal complexes at regular intervals along the ODN stretches. [on SciFinder(R)]
Références
- Titre
- Design and synthesis of novel hybrid metal complex-DNA conjugates: Key building blocks for multimetallic linear DNA nanoarrays.
- Type de publication
- Article de revue
- Année de publication
- 2009
- Auteurs
- Ghosh, Sumana, Pignot-Paintrand Isabelle, Dumy Pascal, and Defrancq Eric
- Revue
- Org. Biomol. Chem.
- Volume
- 7
- Pagination
- 2729–2737
- ISSN
- 1477-0520
- Mots-clés
- hybridization complementary bis oligonucleotide tethered metal complex metal terpyridine DNA conjugate prepn duplex self assembly multimetallic linear DNA nanoarray
- DOI
- 10.1039/b904758a
Soumis le 12 avril 2018