Copper-Promoted Tandem Three-Component Access to Quinazolin-4(H)-imines and Benzimidazo[1,2-c]quinazolines

Abstract: A copper-catalyzed three-component assembly of cyanamides, 2-cyanoarylboronic acids and amines has been developed, providing functionalized quinazolin-4(H)-imines. Subsequent access to benzimidazo[1,2-c]quinazolines is achieved building again on copper-catalysis. One pot hydrolysis of quinazolin-4(H)-imines to quinazolin-4(3H)-ones is also described. Guanidine formation, cyclization and intramolecular C−H bond amination are key features of the process fully mediated by copper.

Références

Titre
Copper-Promoted Tandem Three-Component Access to Quinazolin-4(H)-imines and Benzimidazo[1,2-c]quinazolines
Type de publication
Article de revue
Année de publication
2019
Revue
Advanced Synthesis & Catalysis
Volume
361
Ticket
19
Pagination
4454-4460
Soumis le 29 août 2019