Copper-Catalyzed Enantioselective 1,4-Addition to alpha,beta-Unsaturated Aldehydes
The first asymmetric Cu-catalyzed conjugate addition of dialkylzinc zinc reagents to a large scope of enals in presence of phosphoramidite, SimplePhos, or (R)-BINAP ligands with enantiomeric excesses up to 90% is reported. Moreover, ACA of Grignard reagents afforded moderate to good 1,4-regioselectivities with enantioselectivities up to 90%.
Références
- Titre
- Copper-Catalyzed Enantioselective 1,4-Addition to alpha,beta-Unsaturated Aldehydes
- Type de publication
- Article de revue
- Année de publication
- 2010
- Auteurs
- Palais, Laetitia, Babel Lucille, Quintard Adrien, Belot Sébastien, and Alexakis Alexandre
- Revue
- Organic Letters
- Volume
- 12
- Ticket
- 9
- Pagination
- 1988–1991
- ISSN
- 1523-7060
Soumis le 7 septembre 2022