Copper-Catalyzed Enantioselective 1,4-Addition to alpha,beta-Unsaturated Aldehydes

The first asymmetric Cu-catalyzed conjugate addition of dialkylzinc zinc reagents to a large scope of enals in presence of phosphoramidite, SimplePhos, or (R)-BINAP ligands with enantiomeric excesses up to 90% is reported. Moreover, ACA of Grignard reagents afforded moderate to good 1,4-regioselectivities with enantioselectivities up to 90%.

Références

Titre
Copper-Catalyzed Enantioselective 1,4-Addition to alpha,beta-Unsaturated Aldehydes
Type de publication
Article de revue
Année de publication
2010
Revue
Organic Letters
Volume
12
Ticket
9
Pagination
1988–1991
ISSN
1523-7060
Soumis le 7 septembre 2022