Département de chimie moléculaire

RGD peptides (Arg-Gly-Asp) are known to promote cell adhesion. As a consequence, numerous materials have been functionalized using these peptides for several medical applications. We report herein the controlled functionalization of surfaces to study the influence of RGD d. on cell selectivity. For this purpose, we selected a quartz crystal microbalance QCM-D as this technique allows real-time monitoring of cell adhesion to RGD surfaces. We obsd. that a crit. spacing of nearly 40 nm between RGD ligands is required to observe selective cell adhesion whereas a higher d. is not specific. [on SciFinder(R)]