Département de chimie moléculaire

A novel and simple method of prepn. of 2-alkylaminoquinazolin-4-ones with fused heteroarom. rings, e.g. I, from easily accessible (hetero)arom. amines is described. The method is very efficient, and the 2-alkylaminoquinazolinone derivs. are obtained in three steps without chromatog. purifn. The key step is the ring closure of the N-protected guanidine intermediates by intramol. Friedel-Craft's type substitution. [on SciFinder(R)]