Concise Synthesis of 2-Amino-4(3H)-quinazolinones from Simple (Hetero)aromatic Amines.
A novel and simple method of prepn. of 2-alkylaminoquinazolin-4-ones with fused heteroarom. rings, e.g. I, from easily accessible (hetero)arom. amines is described. The method is very efficient, and the 2-alkylaminoquinazolinone derivs. are obtained in three steps without chromatog. purifn. The key step is the ring closure of the N-protected guanidine intermediates by intramol. Friedel-Craft's type substitution. [on SciFinder(R)]
Références
- Titre
- Concise Synthesis of 2-Amino-4(3H)-quinazolinones from Simple (Hetero)aromatic Amines.
- Type de publication
- Article de revue
- Année de publication
- 2008
- Auteurs
- Zeghida, Walid, Debray Julien, Chierici Sabine, Dumy Pascal, and Demeunynck Martine
- Revue
- J. Org. Chem.
- Volume
- 73
- Pagination
- 2473–2475
- ISSN
- 0022-3263
Soumis le 12 avril 2018