Concise Synthesis of 2-Amino-4(3H)-quinazolinones from Simple (Hetero)aromatic Amines.

A novel and simple method of prepn. of 2-alkylaminoquinazolin-4-ones with fused heteroarom. rings, e.g. I, from easily accessible (hetero)arom. amines is described. The method is very efficient, and the 2-alkylaminoquinazolinone derivs. are obtained in three steps without chromatog. purifn. The key step is the ring closure of the N-protected guanidine intermediates by intramol. Friedel-Craft's type substitution. [on SciFinder(R)]

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Titre
Concise Synthesis of 2-Amino-4(3H)-quinazolinones from Simple (Hetero)aromatic Amines.
Type de publication
Article de revue
Année de publication
2008
Revue
J. Org. Chem.
Volume
73
Pagination
2473–2475
ISSN
0022-3263
Soumis le 12 avril 2018