Concise preparation of optically active heteroaryl α-(hydroxyamino) esters.
A practical sequence for the synthesis of optically active heteroaryl alpha-(hydroxyamino) esters was explored. The highly diastereoselective addn. of heteroaroms. to a cyclic chiral nitrone allowed access to a series of heteroaryl hydroxylamines. The scope of this reaction was evaluated on substrates possessing a pyrrole, an indole, or a furan core. The three-step sequence afforded the alpha-(hydroxyamino) esters in good overall yields (36-62 %) with good enantiomeric excess values (76 to ≥98 %).
Références
- Titre
- Concise preparation of optically active heteroaryl α-(hydroxyamino) esters.
- Type de publication
- Article de revue
- Année de publication
- 2014
- Auteurs
- Murat-Onana, Marie Laure, Berini Christophe, Denis Jean-Noël, Poisson Jean-François, Minassian Frédéric, and Pelloux-Leon Nadia
- Revue
- Eur. J. Org. Chem.
- Volume
- 2014
- Pagination
- 3773–3776
- ISSN
- 1099-0690
Soumis le 12 avril 2018