Catalytic Intramolecular C(sp3)–H Amination of Carbamimidates

The Rh(II)-catalyzed intramolecular C(sp3)–H amination of carbamimidates allowed new nitrogen heterocycles to be isolated in yields up to 99 %. The reaction was best performed in the presence of the Rh2(esp)2 (esp = alpha,alpha′,alpha′-tetramethyl-1,3-benzenedipropionic acid) complex by using 2,2,2-trichloroethoxysulfonyl-protected compounds. The reaction could be applied to substrates possessing a benzylic, an allylic, a propargylic, or a tertiary C(sp3)–H bond.

Références

Titre
Catalytic Intramolecular C(sp3)–H Amination of Carbamimidates
Type de publication
Article de revue
Année de publication
2017
Revue
European Journal of Organic Chemistry
Volume
2017
Pagination
1880–1883
Soumis le 27 septembre 2018