Département de chimie moléculaire

The Rh(II)-catalyzed intramolecular C(sp³)–H amination of carbamimidates allowed new nitrogen heterocycles to be isolated in yields up to 99 %. The reaction was best performed in the presence of the Rh₂(esp)₂ (esp = alpha,alpha′,alpha′-tetramethyl-1,3-benzenedipropionic acid) complex by using 2,2,2-trichloroethoxysulfonyl-protected compounds. The reaction could be applied to substrates possessing a benzylic, an allylic, a propargylic, or a tertiary C(sp³)–H bond.