Département de chimie moléculaire

A practical catalytic asymmetric benzylic C(sp³)–H amination through the intermolecular insertion of a rhodium-bound nitrene species is reported. The reaction of various substrates (used as the limiting component) with the readily accessible sulfamate PfbsNH₂ and the chiral rhodium(II) catalyst Rh₂(S-tfptad)₄ in the presence PhI(OPiv)₂ can be performed on a multigram scale, affording the corresponding benzylic amines with high levels of efficiency and enantiocontrol. This process offers new opportunities for the asymmetric synthesis of amines.