Catalytic Intermolecular C(sp3)–H Amination with Sulfamates for the Asymmetric Synthesis of Amines

A practical catalytic asymmetric benzylic C(sp3)–H amination through the intermolecular insertion of a rhodium-bound nitrene species is reported. The reaction of various substrates (used as the limiting component) with the readily accessible sulfamate PfbsNH2 and the chiral rhodium(II) catalyst Rh2(S-tfptad)4 in the presence PhI(OPiv)2 can be performed on a multigram scale, affording the corresponding benzylic amines with high levels of efficiency and enantiocontrol. This process offers new opportunities for the asymmetric synthesis of amines.

Références

Titre
Catalytic Intermolecular C(sp3)–H Amination with Sulfamates for the Asymmetric Synthesis of Amines
Type de publication
Article de revue
Année de publication
2020
Revue
Organic Process Research & Development
Volume
24
Ticket
5
Pagination
724-728
Soumis le 17 janvier 2020