Catalysis Driven Six-Step Synthesis of Apratoxin A Key Polyketide Fragment

Apratoxin A is a potent anticancer natural product whose key polyketide fragment constitutes a considerable challenge for organic synthesis, with five prior syntheses requiring 12 to 20 steps for its preparation. By combining different redox-economical catalytic stereoselective transformations, the key polyketide fragment could be rapidly prepared. Followed by a site-selective protection of the diol, this strategy enables the preparation of the apratoxin A fragment in only six steps, representing the shortest route to this polyketide.

Références

Titre
Catalysis Driven Six-Step Synthesis of Apratoxin A Key Polyketide Fragment
Type de publication
Article de revue
Année de publication
2022
Revue
Organic Letters
Pagination
asap
ISSN
1523-7060
Soumis le 9 septembre 2022