Catalysis Driven Six-Step Synthesis of Apratoxin A Key Polyketide Fragment
Apratoxin A is a potent anticancer natural product whose key polyketide fragment constitutes a considerable challenge for organic synthesis, with five prior syntheses requiring 12 to 20 steps for its preparation. By combining different redox-economical catalytic stereoselective transformations, the key polyketide fragment could be rapidly prepared. Followed by a site-selective protection of the diol, this strategy enables the preparation of the apratoxin A fragment in only six steps, representing the shortest route to this polyketide.
Références
- Titre
- Catalysis Driven Six-Step Synthesis of Apratoxin A Key Polyketide Fragment
- Type de publication
- Article de revue
- Année de publication
- 2022
- Auteurs
- Shao, Na, Rodriguez Jean, and Quintard Adrien
- Revue
- Organic Letters
- Volume
- 24
- Ticket
- 36
- Pagination
- 6537-6542
- ISSN
- 1523-7060
Soumis le 9 septembre 2022