Département de chimie moléculaire

A new strategy to obtain fluorescent cyclotriveratrylene (CTV) probes is proposed. The key intermediate, a triiodo CTV, is prepd. in 3 steps with 47{%} overall yield. The whole synthesis requires only one purifn. step. The potential of this triiodo CTV as an intermediate is illustrated through the synthesis of a fluorescent phosphorylated probe that is able to bind choline and acetylcholine in pseudo-physiol. conditions, with selectivity towards choline. As a consequence, this intermediate should allow the authors to rapidly form a library of probes to highlight the most promising ones. [on SciFinder(R)]