C3-triiodocyclotriveratrylene as a key intermediate to fluorescent probes: application to selective choline recognition.
A new strategy to obtain fluorescent cyclotriveratrylene (CTV) probes is proposed. The key intermediate, a triiodo CTV, is prepd. in 3 steps with 47{%} overall yield. The whole synthesis requires only one purifn. step. The potential of this triiodo CTV as an intermediate is illustrated through the synthesis of a fluorescent phosphorylated probe that is able to bind choline and acetylcholine in pseudo-physiol. conditions, with selectivity towards choline. As a consequence, this intermediate should allow the authors to rapidly form a library of probes to highlight the most promising ones. [on SciFinder(R)]
Références
- Titre
- C3-triiodocyclotriveratrylene as a key intermediate to fluorescent probes: application to selective choline recognition.
- Type de publication
- Article de revue
- Année de publication
- 2011
- Auteurs
- Peyrard, Lisa, Chierici Sabine, Pinet Sandra, Batat Pinar, Jonusauskas Gediminas, Pinaud Noel, Meyrand Pierre, and Gosse Isabelle.
- Revue
- Org. Biomol. Chem.
- Volume
- 9
- Pagination
- 8489–8494
- ISSN
- 1477-0520
Soumis le 12 avril 2018