C3-triiodocyclotriveratrylene as a key intermediate to fluorescent probes: application to selective choline recognition.

A new strategy to obtain fluorescent cyclotriveratrylene (CTV) probes is proposed. The key intermediate, a triiodo CTV, is prepd. in 3 steps with 47{%} overall yield. The whole synthesis requires only one purifn. step. The potential of this triiodo CTV as an intermediate is illustrated through the synthesis of a fluorescent phosphorylated probe that is able to bind choline and acetylcholine in pseudo-physiol. conditions, with selectivity towards choline. As a consequence, this intermediate should allow the authors to rapidly form a library of probes to highlight the most promising ones. [on SciFinder(R)]

Références

Titre
C3-triiodocyclotriveratrylene as a key intermediate to fluorescent probes: application to selective choline recognition.
Type de publication
Article de revue
Année de publication
2011
Revue
Org. Biomol. Chem.
Volume
9
Pagination
8489–8494
ISSN
1477-0520
Soumis le 12 avril 2018