Aziridination of Cyclic Nitrones Targeting Constrained Iminosugars.

Rare C-7-substituted aziridinyl iminosugars can be synthesized through a short reaction sequence involving 1,3-cycloaddn. of cyclic nitrones with alkynes and a Baldwin rearrangement of isoxazolines into bicyclic 2-acylaziridines. The method is efficient and completely diastereoselective, producing stable aziridinyl iminosugars in high yields.

Références

Titre
Aziridination of Cyclic Nitrones Targeting Constrained Iminosugars.
Type de publication
Article de revue
Année de publication
2017
Revue
Org. Lett.
Volume
19
Pagination
4842–4845
ISSN
1523-7052
Soumis le 12 avril 2018