Aziridination of Cyclic Nitrones Targeting Constrained Iminosugars.
Rare C-7-substituted aziridinyl iminosugars can be synthesized through a short reaction sequence involving 1,3-cycloaddn. of cyclic nitrones with alkynes and a Baldwin rearrangement of isoxazolines into bicyclic 2-acylaziridines. The method is efficient and completely diastereoselective, producing stable aziridinyl iminosugars in high yields.
Références
- Titre
- Aziridination of Cyclic Nitrones Targeting Constrained Iminosugars.
- Type de publication
- Article de revue
- Année de publication
- 2017
- Auteurs
- Tangara, Salia, Aupic Clara, Kanazawa Alice, Poisson Jean-François, and Py Sandrine
- Revue
- Org. Lett.
- Volume
- 19
- Pagination
- 4842–4845
- ISSN
- 1523-7052
Soumis le 12 avril 2018