Asymmetric Catalytic Alkynylation of Acetaldehyde: Application to the Synthesis of (+)-Tetrahydropyrenophorol

In control: By controlling the kinetics of alkynylation over aldolization, the challenging asymmetric catalytic alkynylation of acetaldehyde has been realized. The resulting products are attractive synthons which are produced with good to excellent enantiocontrol, and show broad tolerance and applicability, as demonstrated by the synthesis (+)-tetrahydropyrenophorol.

Références

Titre
Asymmetric Catalytic Alkynylation of Acetaldehyde: Application to the Synthesis of (+)-Tetrahydropyrenophorol
Type de publication
Article de revue
Année de publication
2012
Revue
Angewandte Chemie International Edition
Volume
51
Ticket
27
Pagination
6704–6708
Soumis le 7 septembre 2022