Asymmetric Approach to Hyacinthacines B1 and B2.

Naturally occurring hyacinthacines B1 and B2 (I and II, resp.) have been prepd. from a common, easily available, advanced intermediate. The approach features several highly stereoselective transformations: inter alia, a dichloroketene-enol ether [2 + 2] cycloaddn., a Bruylants alkylation, and an amino-nitrile alkylation-redn.


Soumis le 12 avril 2018