Asymmetric addition of aryloxy ethynyl lithium derivatives to N-sulfinyl imines.

Aryloxy ethynyl lithium species can be generated in di-Et ether and efficiently added to aliph. and arom. N-sulfinyl imines in THF, affording aryloxypropargyl sulfinamides in good yield, and in most cases high diastereoselectivity. The diastereoselectivity can be reversed by precomplexation of the N-sulfinyl imine with BF3·OEt2.

Références

Titre
Asymmetric addition of aryloxy ethynyl lithium derivatives to N-sulfinyl imines.
Type de publication
Article de revue
Année de publication
2013
Revue
Monatsh. Chem.
Volume
144
Pagination
455–460
ISSN
0026-9247
Soumis le 12 avril 2018