Asymmetric addition of alpha-hetero-disubstituted aldehydes to vinyl sulfones; formation of highly functionalized tetrasubstituted carbon centres
Aminal–pyrrolidine catalysed addition of alpha-hetero-disubstituted aldehydes to vinyl sulfones is described in high enantioselectivity (ee up to 97%). The obtained adducts can easily be converted to enantioenriched synthons as for example 2,2-dialkylepoxide. Evidence for a kinetic resolution is also observed.
Références
- Titre
- Asymmetric addition of alpha-hetero-disubstituted aldehydes to vinyl sulfones; formation of highly functionalized tetrasubstituted carbon centres
- Type de publication
- Article de revue
- Année de publication
- 2010
- Auteurs
- Quintard, Adrien, and Alexakis Alexandre
- Revue
- Chem. Commun.
- Volume
- 46
- Ticket
- 23
- Pagination
- 4085–4087
- DOI
- 10.1039/C000326C
Soumis le 7 septembre 2022