Assessment of new 2'-O-acetalester protecting groups for regular RNA synthesis and original 2'-modified proRNA
New base-labile acyloxymethyl groups were evaluated to protect 2'-OH functions of ribonucleotides for regular RNA synthesis in order to shorten the deprotection procedure upon ammonia. These same acetalester groups were assessed in 2'-modified proRNA as biolabile 2'-protections removable by cell enzymes to generate parent RNA. Demasking of 2'-modified pro-uridylates was studied in cell extracts.
Références
- Titre
- Assessment of new 2'-O-acetalester protecting groups for regular RNA synthesis and original 2'-modified proRNA
- Type de publication
- Article de revue
- Année de publication
- 2009
- Auteurs
- Martin, A. R., Lavergne Thomas, Vasseur J. J., and Debart F.
- Revue
- Bioorganic & Medicinal Chemistry Letters
- Volume
- 19
- Pagination
- 4046-9
Soumis le 5 juillet 2018