Are Human Tyrosinase and Related Proteins Suitable Targets for Melanoma Therapy?.

Among the human copper-contg. monooxygenases, Tyrosinase (Ty) is an important enzyme involved in the determinant step of the biosynthetic pathway of melanin pigment. In this pathway, Ty catalyzes the tyrosine monooxygenation into L-DOPA-quinone, which is the precursor of the skin pigment melanin. Ty inhibitors/activators are a well-established approach for controlling in vivo melanin prodn., so their development has a huge economical and industrial impact. Moreover, recent publications highlight that targeting tyrosinase with inhibitors/activators to treat melanogenesis disorders is one of many possible approaches, due to the complex biochem. reaction involved in the melanin synthesis. [on SciFinder(R)]

Références

Titre
Are Human Tyrosinase and Related Proteins Suitable Targets for Melanoma Therapy?.
Type de publication
Article de revue
Année de publication
2016
Revue
Curr. Top. Med. Chem. (Sharjah, United Arab Emirates)
Volume
16
Pagination
3033–3047
ISSN
1568-0266
Soumis le 12 avril 2018