Are Human Tyrosinase and Related Proteins Suitable Targets for Melanoma Therapy?.
Among the human copper-contg. monooxygenases, Tyrosinase (Ty) is an important enzyme involved in the determinant step of the biosynthetic pathway of melanin pigment. In this pathway, Ty catalyzes the tyrosine monooxygenation into L-DOPA-quinone, which is the precursor of the skin pigment melanin. Ty inhibitors/activators are a well-established approach for controlling in vivo melanin prodn., so their development has a huge economical and industrial impact. Moreover, recent publications highlight that targeting tyrosinase with inhibitors/activators to treat melanogenesis disorders is one of many possible approaches, due to the complex biochem. reaction involved in the melanin synthesis. [on SciFinder(R)]
Références
- Titre
- Are Human Tyrosinase and Related Proteins Suitable Targets for Melanoma Therapy?.
- Type de publication
- Article de revue
- Année de publication
- 2016
- Auteurs
- Buitrago, Elina, Hardre Renaud, Haudecoeur Romain, Jamet Hélène, Belle Catherine, Boumendjel Ahcene, Bubacco Luigi, and Reglier Marius.
- Revue
- Curr. Top. Med. Chem. (Sharjah, United Arab Emirates)
- Volume
- 16
- Pagination
- 3033–3047
- ISSN
- 1568-0266
Soumis le 12 avril 2018