Application of Chiral Sulfinamides into Formation and Reduction of Sulfinylketimines to Obtain Valuable alpha-Chiral Primary Amines

Chiral sulfinamides are very valuable, commercially available, and easy to handle chiral auxiliaries. One of the most interesting transformations that can be performed with a chiral sulfinamide is its condensation onto a ketone to form a chiral sulfinylketimine, followed by a reduction to obtain an alpha-chiral primary amine. We review here all the methodologies developed around this condensation/reduction transformation. In the second part, we survey applications of these newly developed methodologies for the synthesis of valuable biologically active compounds, including multikilogram scale synthesis.

Références

Titre
Application of Chiral Sulfinamides into Formation and Reduction of Sulfinylketimines to Obtain Valuable alpha-Chiral Primary Amines
Type de publication
Article de revue
Année de publication
2020
Revue
European Journal of Organic Chemistry
Ticket
37
Pagination
5901-5916
Soumis le 2 septembre 2020