Application of Chiral Sulfinamides into Formation and Reduction of Sulfinylketimines to Obtain Valuable alpha-Chiral Primary Amines
Chiral sulfinamides are very valuable, commercially available, and easy to handle chiral auxiliaries. One of the most interesting transformations that can be performed with a chiral sulfinamide is its condensation onto a ketone to form a chiral sulfinylketimine, followed by a reduction to obtain an alpha-chiral primary amine. We review here all the methodologies developed around this condensation/reduction transformation. In the second part, we survey applications of these newly developed methodologies for the synthesis of valuable biologically active compounds, including multikilogram scale synthesis.
Références
- Titre
- Application of Chiral Sulfinamides into Formation and Reduction of Sulfinylketimines to Obtain Valuable alpha-Chiral Primary Amines
- Type de publication
- Article de revue
- Année de publication
- 2020
- Auteurs
- Achuenu, Chukuka, Carret Sébastien, Poisson Jean-François, and Berthiol Florian
- Revue
- European Journal of Organic Chemistry
- Ticket
- 37
- Pagination
- 5901-5916
Soumis le 2 septembre 2020