Aldehydic Oligonucleotide: A Key Intermediate for the Preparation of Oligonucleotide Conjugates Through Oxime Bond Formation.

Oligonucleotides functionalized with an aldehyde group are the key intermediates used for the prepn. of peptide-oligonucleotide conjugates through the formation of an oxime linkage. Herein, we describe a brief overview of various synthetic protocols developed in our lab. for the prepn. of aldehyde contg. oligonucleotides and their subsequent conjugation with peptides. [on SciFinder(R)]

Références

Titre
Aldehydic Oligonucleotide: A Key Intermediate for the Preparation of Oligonucleotide Conjugates Through Oxime Bond Formation.
Type de publication
Article de revue
Année de publication
2007
Revue
Nucleosides. Nucleotides Nucleic Acids
Volume
26
Pagination
883–887
ISSN
1525-7770
Soumis le 12 avril 2018