Activation of 1,2- and 1,3-Ketoamides with Thiourea Organocatalyst for the Enantioselective Domino Synthesis of Functionalized Cyclohexanes
Several reactive sites of 1,2- and 1,3-ketoamides were successively exploited in two complementary domino transformations for the synthesis of polysubstituted monocyclic or bridged bicyclic cyclohexanes, with the creation of up to six stereogenic centers. In both cases, a chiral bifunctional thiourea organocatalyst allowed efficient control of chirality in the final carbocycle.
Références
- Titre
- Activation of 1,2- and 1,3-Ketoamides with Thiourea Organocatalyst for the Enantioselective Domino Synthesis of Functionalized Cyclohexanes
- Type de publication
- Article de revue
- Année de publication
- 2013
- Auteurs
- Raimondi, Wilfried, Duque Maria del Mar Sa, Goudedranche Sébastien, Quintard Adrien, Constantieux Thierry, Bugaut Xavier, Bonne Damien, and Rodriguez Jean
- Revue
- Synthesis
- Volume
- 45
- Ticket
- 12
- Pagination
- 1659–1666
- ISSN
- 0039-7881 DOI - 10.1055/s-0033-1338844
Soumis le 7 septembre 2022