Activatable probes for non-invasive small animal fluorescence imaging.

Fluorescence tomog. today appears as a complementary imaging modality for assessing mol. processes in small living animals. A new design of fluorescent activatable units for the imaging of cellular internalization of probes is proposed. Disulfide bridges are used as intracellular cleavable bounds for fluorescence activation. These units are not activated in blood, neither in vitro nor in mouse, but specifically in the presence of lysed cells or a chem. reducer. The authors therefore expect that the use of such activatable units, grafted to targeting moieties, will improve significantly the contrast of images obtained in the future. [on SciFinder(R)]

Références

Titre
Activatable probes for non-invasive small animal fluorescence imaging.
Type de publication
Article de revue
Année de publication
2007
Revue
Nucl. Instruments Methods Phys. Res. Sect. A Accel. Spectrometers, Detect. Assoc. Equip.
Volume
571
Pagination
165–168
ISSN
0168-9002
Soumis le 12 avril 2018