Activatable probes for non-invasive small animal fluorescence imaging.
Fluorescence tomog. today appears as a complementary imaging modality for assessing mol. processes in small living animals. A new design of fluorescent activatable units for the imaging of cellular internalization of probes is proposed. Disulfide bridges are used as intracellular cleavable bounds for fluorescence activation. These units are not activated in blood, neither in vitro nor in mouse, but specifically in the presence of lysed cells or a chem. reducer. The authors therefore expect that the use of such activatable units, grafted to targeting moieties, will improve significantly the contrast of images obtained in the future. [on SciFinder(R)]
Références
- Titre
- Activatable probes for non-invasive small animal fluorescence imaging.
- Type de publication
- Article de revue
- Année de publication
- 2007
- Auteurs
- Texier, Isabelle, Razkin Jesus, Josserand Veronique, Boturyn Didier, Dumy Pascal, Coll Jean-Luc, and Rizo Philippe.
- Revue
- Nucl. Instruments Methods Phys. Res. Sect. A Accel. Spectrometers, Detect. Assoc. Equip.
- Volume
- 571
- Pagination
- 165–168
- ISSN
- 0168-9002
Soumis le 12 avril 2018