Accessing Enantiopure Endocyclic Sulfoximines Through Catalytic Cycloisomerisation of Oxygenated Propargyl-Sulfinamides

In this study, a novel strategy to access endocyclic sulfoximines in an enantiopure form is reported. The approach is based on a silver nitrate-catalyzed cyclo-isomerization reaction of oxygenated propargylic sulfinamides and provides efficiently 5-membered endocyclic sulfoximines (isothiazole 1-oxide). These new heterocyclic scaffolds can be isolated or directly converted into cyclic sulfinamides via Lewis acid-mediated sulphur dealkylation reactions.

Références

Titre
Accessing Enantiopure Endocyclic Sulfoximines Through Catalytic Cycloisomerisation of Oxygenated Propargyl-Sulfinamides
Type de publication
Article de revue
Année de publication
2019
Revue
Advanced Synthesis & Catalysis
Volume
361
Ticket
6
Start Page
1236
Pagination
1236-1240
Date de publication
12/2018
Soumis le 13 janvier 2019